標題: Positive association between hypertension and urinary bladder cancer: epidemiologic evidence involving 79,236 propensity score-matched individuals
作者: Kok, Victor C.
Zhang, Han-Wei
Lin, Chin-Teng
Huang, Shih-Chung
Wu, Ming-Feng
電機工程學系
腦科學研究中心
Department of Electrical and Computer Engineering
Brain Research Center
關鍵字: Essential hypertension;population-based cohort study;propensity analysis;urinary bladder cancer
公開日期: 1-Jan-2018
摘要: Introduction: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. Material and methods: We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes. We constructed multivariable Cox models to derive adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Cumulative incidence was compared using a log-rank test. Results: During a total follow-up duration of 380,525 and 372,020 person-years in the hypertension and COMP groups, 248 and 186 patients developed UB cancer, respectively, representing a 32% increase in the risk (aHR, 1.32; 95% CI, 1.09-1.60). Hypertensive women harbored a significantly increased risk of UB cancer (aHR, 1.55; 95% CI, 1.12-2.13) compared with non-hypertensive women, whereas men with hypertension had a statistically non-significant increased risk (aHR, 1.22; 95% CI, 0.96-1.55). The sensitivity analysis demonstrated that the increased risk was sustained throughout different follow-up durations for the entire cohort; a statistical increase in the risk was also noted among hypertensive men. Conclusion: This nationwide population-based propensity score-matched cohort study supports a positive association between hypertension and subsequent UB cancer development.
URI: http://dx.doi.org/10.1080/03009734.2018.1473534
http://hdl.handle.net/11536/145244
ISSN: 0300-9734
DOI: 10.1080/03009734.2018.1473534
期刊: UPSALA JOURNAL OF MEDICAL SCIENCES
Volume: 123
起始頁: 109
結束頁: 115
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