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dc.contributor.authorWang, Sin-Geen_US
dc.contributor.authorChen, Yen-Chunen_US
dc.contributor.authorChen, Yu-Chieen_US
dc.date.accessioned2018-08-21T05:53:52Z-
dc.date.available2018-08-21T05:53:52Z-
dc.date.issued2018-06-01en_US
dc.identifier.issn1743-5889en_US
dc.identifier.urihttp://dx.doi.org/10.2217/nnm-2017-0380en_US
dc.identifier.urihttp://hdl.handle.net/11536/145267-
dc.description.abstractAim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15 degrees C under irradiation by a near-infrared laser (lambda = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.en_US
dc.language.isoen_USen_US
dc.subjectantibacterial agentsen_US
dc.subjectgold nanoparticlesen_US
dc.subjectmultivalent interactionsen_US
dc.subjectnear infrared (NIR)en_US
dc.subjectphotothermalen_US
dc.subjectvancomycinen_US
dc.subjectvancomycin-resistant Enterococcien_US
dc.titleAntibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteriaen_US
dc.typeArticleen_US
dc.identifier.doi10.2217/nnm-2017-0380en_US
dc.identifier.journalNANOMEDICINEen_US
dc.citation.volume13en_US
dc.citation.spage1405en_US
dc.citation.epage1416en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000438860100002en_US
Appears in Collections:Articles