標題: | Biocompatible D-A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy |
作者: | Zhang, Jinfeng Yang, Caixia Zhang, Rui Chen, Rui Zhang, Zhenyu Zhang, Wenjun Peng, Shih-Hao Chen, Xiaoyuan Liu, Gang Hsu, Chain-Shu Lee, Chun-Sing 應用化學系 Department of Applied Chemistry |
公開日期: | 5-四月-2017 |
摘要: | The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent. Combined with additional merits including donor-acceptor pair to favor electron transfer and fluorescence quenching effect after NP formation, the photothermal conversion efficiency of the PPor-PEG NPs is determined to be 62.3%, which is the highest value among reported polymer NPs. Moreover, the as-prepared PPor-PEG NP not only exhibits a remarkable cell-killing ability but also achieves 100% tumor elimination, demonstrating its excellent photothermal therapeutic efficacy. Finally, the as-prepared water-dispersible PPor-PEG NPs show good biocompatibility and biosafety, making them a promising candidate for future clinical applications in cancer theranostics. |
URI: | http://dx.doi.org/10.1002/adfm.201605094 http://hdl.handle.net/11536/145302 |
ISSN: | 1616-301X |
DOI: | 10.1002/adfm.201605094 |
期刊: | ADVANCED FUNCTIONAL MATERIALS |
Volume: | 27 |
顯示於類別: | 期刊論文 |