標題: Biocompatible D-A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy
作者: Zhang, Jinfeng
Yang, Caixia
Zhang, Rui
Chen, Rui
Zhang, Zhenyu
Zhang, Wenjun
Peng, Shih-Hao
Chen, Xiaoyuan
Liu, Gang
Hsu, Chain-Shu
Lee, Chun-Sing
應用化學系
Department of Applied Chemistry
公開日期: 5-Apr-2017
摘要: The development of nanotheranostic agents that integrate diagnosis and therapy for effective personalized precision medicine has obtained tremendous attention in the past few decades. In this report, biocompatible electron donor-acceptor conjugated semiconducting polymer nanoparticles (PPor-PEG NPs) with light-harvesting unit is prepared and developed for highly effective photoacoustic imaging guided photothermal therapy. To the best of our knowledge, it is the first time that the concept of light-harvesting unit is exploited for enhancing the photoacoustic signal and photothermal energy conversion in polymer-based theranostic agent. Combined with additional merits including donor-acceptor pair to favor electron transfer and fluorescence quenching effect after NP formation, the photothermal conversion efficiency of the PPor-PEG NPs is determined to be 62.3%, which is the highest value among reported polymer NPs. Moreover, the as-prepared PPor-PEG NP not only exhibits a remarkable cell-killing ability but also achieves 100% tumor elimination, demonstrating its excellent photothermal therapeutic efficacy. Finally, the as-prepared water-dispersible PPor-PEG NPs show good biocompatibility and biosafety, making them a promising candidate for future clinical applications in cancer theranostics.
URI: http://dx.doi.org/10.1002/adfm.201605094
http://hdl.handle.net/11536/145302
ISSN: 1616-301X
DOI: 10.1002/adfm.201605094
期刊: ADVANCED FUNCTIONAL MATERIALS
Volume: 27
Appears in Collections:Articles