標題: IL-28 and IL-29 as protective markers in subject with dengue fever
作者: Hung, Chih-Hsing
Huang, Chung-Hao
Wang, Lin
Huang, Chun-Chi
Wu, Meng-Chieh
Chin, Yi-Ying
Lin, Chun-Yu
Chang, Ko
Wu, Deng-Chyang
Chen, Yen-Hsu
生物科技學系
Department of Biological Science and Technology
關鍵字: IL-28;IL-29;Dengue fever;Interferon
公開日期: 1-Jun-2017
摘要: About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (n = 45) and control group (n = 24) were included prospectively. Clinical symptoms and laboratory data were collected from every patient. We investigated IL-28 and IL-29 levels in serum by ELISA. The concentrations of serum IL-28 and IL-29 were significantly higher in subjects with dengue when compared to those of control group. The patients with higher serum IL-28 and IL-29 levels had significantly lower ALAT and peripheral blood neutrophil percentage, but higher peripheral platelet, total white blood cell (WBC), monocyte, and lymphocyte counts. Patients with higher serum IL-28 and IL-29 levels also had more flu-like symptoms, but less vomiting. Increased level of IL-28 and IL-29 was associated with better liver function, platelet and WBC numbers and clinical symptom in subjects with dengue and could potentially serve as a protective marker.
URI: http://dx.doi.org/10.1007/s00430-017-0498-x
http://hdl.handle.net/11536/145448
ISSN: 0300-8584
DOI: 10.1007/s00430-017-0498-x
期刊: MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Volume: 206
起始頁: 217
結束頁: 223
Appears in Collections:Articles