標題: Epidemiology and trends in the antibiotic susceptibilities of Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region, 2010-2013
作者: Chang, Ya-Ting
Coombs, Geoffrey
Ling, Thomas
Balaji, V.
Rodrigues, Camilla
Mikamo, Hiroshige
Kim, Min-Ja
Rajasekaram, Datin Ganeswrie
Mendoza, Myrna
Tan, Thean Yen
Kiratisin, Pattarachai
Ni, Yuxing
Barry, Weinman
Xu, Yingchun
Chen, Yen-Hsu
Hsueh, Po-Ren
生醫工程研究所
Institute of Biomedical Engineering
關鍵字: Antimicrobial susceptibility;Epidemiology;Gram-negative bacilli;Intra-abdominal infection;Extended-spectrum beta-lactamase;Asia-Pacific region
公開日期: 1-Jun-2017
摘要: This study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of Gram-negative bacilli (GNB) isolated from intra-abdominal infections (IAIs) in the Asia-Pacific region (APR) from 2010-2013. A total of 17 350 isolates were collected from 54 centres in 13 countries in the APR. The three most commonly isolated GNB were Escherichia coli (46.1%), Klebsiella pneumoniae (19.3%) and Pseudomonas aeruginosa (9.8%). Overall, the rates of extended-spectrum beta-lactamase (ESBL)-producing E. coli and K. pneumoniae were 38.2% and 24.3%, respectively, and they were highest in China (66.6% and 38.7%, respectively), Thailand (49.8% and 36.5%, respectively) and Vietnam (47.9% and 30.4%, respectively). During 2010-2013, the rates of ESBL-producing E. coli and K. pneumoniae isolates causing community-associated (CA) IAIs (collected <48 h after admission) were 26.0% and 13.5%, respectively, and those causing hospital-associated (HA) IAIs were 48.0% and 30.6%, respectively. Amikacin, ertapenem and imipenem were the most effective agents against ESBL-producing isolates. Piperacillin/tazobactam displayed good in vitro activity (91.4%) against CA ESBL-producing E. coli. For other commonly isolated Enterobacteriaceae, fluoroquinolones, cefepime and carbapenems exhibited better in vitro activities than third-generation cephalosporins. Amikacin possessed high in vitro activity against all GNB isolates (>80%) causing IAIs, except for Acinetobacter calcoaceticus-baumannii (ACB) complex (30.9% for HA-IAI isolates). All of the antimicrobial agents tested exhibited <45% in vitro activity against ACB complex. Antimicrobial resistance is a persistent threat in the APR and continuous monitoring of evolutionary trends in the susceptibility patterns of GNB causing IAIs in this region is mandatory. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ijantimicag.2017.01.030
http://hdl.handle.net/11536/145578
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2017.01.030
期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume: 49
起始頁: 734
結束頁: 739
Appears in Collections:Articles