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dc.contributor.authorLiu, Pu-Steen_US
dc.contributor.authorWang, Haipingen_US
dc.contributor.authorLi, Xiaoyunen_US
dc.contributor.authorChao, Tungen_US
dc.contributor.authorTeav, Tonyen_US
dc.contributor.authorChristen, Stefanen_US
dc.contributor.authorDi Conza, Giusyen_US
dc.contributor.authorCheng, Wan-Chenen_US
dc.contributor.authorChou, Chih-Hungen_US
dc.contributor.authorVavakova, Magdalenaen_US
dc.contributor.authorMuret, Charlotteen_US
dc.contributor.authorDebackere, Koenen_US
dc.contributor.authorMazzone, Massimilianoen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorFendt, Sarah-Mariaen_US
dc.contributor.authorIvanisevic, Julijanaen_US
dc.contributor.authorHo, Ping-Chihen_US
dc.date.accessioned2018-08-21T05:54:26Z-
dc.date.available2018-08-21T05:54:26Z-
dc.date.issued2017-09-01en_US
dc.identifier.issn1529-2908en_US
dc.identifier.urihttp://dx.doi.org/10.1038/ni.3796en_US
dc.identifier.urihttp://hdl.handle.net/11536/145951-
dc.description.abstractGlutamine metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the underlying mechanisms regulated by glutamine metabolism to orchestrate macrophage activation remain unclear. Here we show that the production of alpha-ketoglutarate (alpha KG) via glutaminolysis is important for alternative (M2) activation of macrophages, including engagement of fatty acid oxidation (FAO) and Jmjd3-dependent epigenetic reprogramming of M2 genes. This M2-promoting mechanism is further modulated by a high alpha KG/succinate ratio, whereas a low ratio strengthens the proinflammatory phenotype in classically activated (M1) macrophages. As such, aKG contributes to endotoxin tolerance after M1 activation. This study reveals new mechanistic regulations by which glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.en_US
dc.language.isoen_USen_US
dc.titlealpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogrammingen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/ni.3796en_US
dc.identifier.journalNATURE IMMUNOLOGYen_US
dc.citation.volume18en_US
dc.citation.spage985en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000408137700008en_US
Appears in Collections:Articles