標題: Multifunctional Fe(3)O(4)/alumina core/shell MNPs as photothermal agents for targeted hyperthermia of nosocomial and antibiotic-resistant bacteria
作者: Yu, Tsai-Jung
Li, Po-Han
Tseng, Te-Wei
Chen, Yu-Chie
應用化學系
Department of Applied Chemistry
公開日期: 1-十月-2011
摘要: The appearance of antibiotic-resistant bacterial strains is a serious problem in medical treatment. Thus, it is imperative to explore new therapeutic approaches and antibiotics with which to treat patients suffering from bacterial infections. Materials & Methods: In this work, we propose a targeted hyperthermia therapeutic approach using alumina-coated iron oxide magnetic nanoparticles (Fe(3)O(4)/alumina core/shell MNPs) as photothermal agents to selectively kill bacteria. Results: Fe(3)O(4) MNPs possess photothermal capabilities under near-infrared (NIR) light illumination. The temperature of the MNP suspension (1.33 mu g/mu l, 60 mu l) under illumination with NIR light increased 20 degrees C over 5 min. Functionalization of the surface of the MNPs with an alumina coating allows them to have targeting capability toward bacteria. The prepared Fe(3)O(4)/alumina core/shell MNPs possess several desirable features, including magnetic properties, absorption capability in the NIR region and the ability to target bacteria. The magnetic properties of the Fe(3)O(4)/alumina MNPs allow conjugated target species to aggregate at a specific location under a magnetic field. A NIR laser can then be used to specifically irradiate the aggregated spot to photokill target bacteria. The cell growth of nosocomial bacteria, including Gram-positive, Gram-negative and antibiotic-resistant bacterial strains, can be effectively inhibited by over 95% within 10 min of light irradiation when targeted by Fe(3)O(4)/alumina MNPs. Conclusion: This approach provides a potential therapeutic approach for treating patients suffering from nosocomial and antibiotic-resistant bacterial infections.
URI: http://dx.doi.org/10.2217/nnm.11.34
http://hdl.handle.net/11536/14761
ISSN: 1743-5889
DOI: 10.2217/nnm.11.34
期刊: NANOMEDICINE
Volume: 6
Issue: 8
起始頁: 1353
結束頁: 1363
顯示於類別:期刊論文