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dc.contributor.authorSaddik, Abdelreheem Abdelfatahen_US
dc.contributor.authorEl-Dean, Adel Mohamed Kamalen_US
dc.contributor.authorEl-Said, Waleed Ahmeden_US
dc.contributor.authorHassan, Khairy Mohameden_US
dc.contributor.authorAbbady, Mohamed Saaden_US
dc.date.accessioned2019-04-02T05:58:00Z-
dc.date.available2019-04-02T05:58:00Z-
dc.date.issued2018-09-01en_US
dc.identifier.issn0022-152Xen_US
dc.identifier.urihttp://dx.doi.org/10.1002/jhet.3256en_US
dc.identifier.urihttp://hdl.handle.net/11536/148136-
dc.description.abstractA new series from thieno[2,3-d] pyrimidine derivatives have been synthesized based on 2-(ethylmercapto)-4-mercapto-6-phenyl-5-pyrimidine carbonitrile, these compounds used in the synthesis of many pyrimidothienopyrimidine derivatives and triazolo[1,5:1,6]pyrimido[4,5:4,5]thieno[2,3-d] pyrimidine derivatives. The chemical composition of these compounds was confirmed by H-1 NMR, C-13 NMR, and MS techniques. Some of the synthesized compounds were screened for their antimicrobial and anticancer agent. Compound (9b) showed strong effect on Aspergillus Fumigatus (RCMB 2568), Candida albicans (RCMB 05036), Saphylococcus aureus (RCMB 010010), Bacillissubtilis (RCMB 010067), Salmonella sp. (RCMB 010043), and Escherichia coli (RCMB 010052). Compounds (2) and (5a-k) were evaluated for their IC50 values against two cancer cell lines (MCF-7 and HeLa cells) in the presence of Paclitaxel as reference material. Compound (5g) showed the highest cytotoxicity against MCF-7 (IC50 values about 18.87 +/- 0.2g/mL) cells compared with Paclitaxel (IC50 values about 40.37 +/- 1.7g/mL). Also, compound (5d) showed the highest cytotoxicity against HeLa (IC50 values about 40.74 +/- 1.7g/mL) cells compared with Paclitaxel (IC50 values about 45.78 +/- 0.8g/mL).en_US
dc.language.isoen_USen_US
dc.titleSynthesis, Antimicrobial, and Anticancer Activities of a New Series of Thieno[2,3-d] Pyrimidine Derivativesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jhet.3256en_US
dc.identifier.journalJOURNAL OF HETEROCYCLIC CHEMISTRYen_US
dc.citation.volume55en_US
dc.citation.spage2111en_US
dc.citation.epage2122en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000444416900013en_US
dc.citation.woscount1en_US
Appears in Collections:Articles