標題: Printable Graphene Oxide Micropatterns for a Bio-Subretinal Chip
作者: Yang, Jia-Wei
Tseng, Ming-Liang
Fu, Yu-Min
Kang, Che-Hao
Cheng, Yu-Ting
Kuo, Po-Han
Tzeng, Chi-Kuan
Chiou, Shih-Hwa
Wu, Chung-Yu
Chen, Guan-Yu
交大名義發表
生物科技學系
電子工程學系及電子研究所
電機工程學系
National Chiao Tung University
Department of Biological Science and Technology
Department of Electronics Engineering and Institute of Electronics
Department of Electrical and Computer Engineering
關鍵字: graphene oxide;inkjet printing;micropatterns;retinal pigment epithelium cells;subretinal chips
公開日期: 19-九月-2018
摘要: Recently, implantable artificial subretinal chips using electronic components have replaced photoreceptors to serve as the most feasible treatment for retinal diseases. As such a chip that is meant to be implanted and used for very long periods, growing retinal cells on it to improve the electrical stimulation efficiency and attraction of neuronal elements remains a challenge. Here, an inkjet printing technology is employed to create graphene oxide (GO) micropatterns onto microelectrodes of a photovoltaic-powered implantable retinal chip. These GO micropatterns allow human retinal pigment epithelium (RPE) cells to specially attach and grow in each microelectrode. In addition, the cell proliferation, viability, and tight junction of RPE cells are improved during culturing. The development of a simple surface-coating technology would pave the way for the development of the first fully integrated and encapsulated retinal prostheses with biocompatible on-chip microelectrodes for long-term implantation, which could be effectively applied in retina tissue engineering and therapy.
URI: http://dx.doi.org/10.1002/adhm.201800365
http://hdl.handle.net/11536/148239
ISSN: 2192-2640
DOI: 10.1002/adhm.201800365
期刊: ADVANCED HEALTHCARE MATERIALS
Volume: 7
顯示於類別:期刊論文