標題: | Printable Graphene Oxide Micropatterns for a Bio-Subretinal Chip |
作者: | Yang, Jia-Wei Tseng, Ming-Liang Fu, Yu-Min Kang, Che-Hao Cheng, Yu-Ting Kuo, Po-Han Tzeng, Chi-Kuan Chiou, Shih-Hwa Wu, Chung-Yu Chen, Guan-Yu 交大名義發表 生物科技學系 電子工程學系及電子研究所 電機工程學系 National Chiao Tung University Department of Biological Science and Technology Department of Electronics Engineering and Institute of Electronics Department of Electrical and Computer Engineering |
關鍵字: | graphene oxide;inkjet printing;micropatterns;retinal pigment epithelium cells;subretinal chips |
公開日期: | 19-九月-2018 |
摘要: | Recently, implantable artificial subretinal chips using electronic components have replaced photoreceptors to serve as the most feasible treatment for retinal diseases. As such a chip that is meant to be implanted and used for very long periods, growing retinal cells on it to improve the electrical stimulation efficiency and attraction of neuronal elements remains a challenge. Here, an inkjet printing technology is employed to create graphene oxide (GO) micropatterns onto microelectrodes of a photovoltaic-powered implantable retinal chip. These GO micropatterns allow human retinal pigment epithelium (RPE) cells to specially attach and grow in each microelectrode. In addition, the cell proliferation, viability, and tight junction of RPE cells are improved during culturing. The development of a simple surface-coating technology would pave the way for the development of the first fully integrated and encapsulated retinal prostheses with biocompatible on-chip microelectrodes for long-term implantation, which could be effectively applied in retina tissue engineering and therapy. |
URI: | http://dx.doi.org/10.1002/adhm.201800365 http://hdl.handle.net/11536/148239 |
ISSN: | 2192-2640 |
DOI: | 10.1002/adhm.201800365 |
期刊: | ADVANCED HEALTHCARE MATERIALS |
Volume: | 7 |
顯示於類別: | 期刊論文 |