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dc.contributor.authorCheng, Cheng-Hsiangen_US
dc.contributor.authorTsai, Ping-Yuanen_US
dc.contributor.authorYang, Tzu-Yien_US
dc.contributor.authorCheng, Wan-Hsuehen_US
dc.contributor.authorYen, Ting-Yangen_US
dc.contributor.authorLuo, Zhicongen_US
dc.contributor.authorQian, Xin-Hongen_US
dc.contributor.authorChen, Zhi-Xinen_US
dc.contributor.authorLin, Tzu-Hanen_US
dc.contributor.authorChen, Wei-Hongen_US
dc.contributor.authorChen, Wei-Mingen_US
dc.contributor.authorLiang, Sheng-Fuen_US
dc.contributor.authorShaw, Fu-Zenen_US
dc.contributor.authorChang, Cheng-Siuen_US
dc.contributor.authorHsin, Yue-Loongen_US
dc.contributor.authorLee, Chen-Yien_US
dc.contributor.authorKer, Ming-Douen_US
dc.contributor.authorWu, Chung-Yuen_US
dc.date.accessioned2019-04-02T05:59:57Z-
dc.date.available2019-04-02T05:59:57Z-
dc.date.issued2018-11-01en_US
dc.identifier.issn0018-9200en_US
dc.identifier.urihttp://dx.doi.org/10.1109/JSSC.2018.2867293en_US
dc.identifier.urihttp://hdl.handle.net/11536/148400-
dc.description.abstractA 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal acquisition unit (NSAU), a biosignal processor (BSP), a 16-channel high-voltage-tolerant stimulator (HVTS), and wireless power and bidirectional data telemetry are designed. In the NSAU, the input protection circuit is used to prevent MOSFET from overstressing by the high-voltage stimulations. Hence, NSAUs can share electrodes with stimulators. The auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIAs) are designed with the chopper-stabilized technique with a new offset reduction loop. The measured input-referred noise is 2.09 mu V-rms and the noise-efficiency factor (NEF) is 3.78. The entropy-and-spectrum seizure detection algorithm is implemented in the BSP with 0.76-s seizure detection latency and 97.8% detection accuracy. When the seizure onset is detected by the BSP, the HVTS with adaptive supply control delivers 0.5-3-mA biphasic current stimulation to suppress the seizure onset. The proposed SoC is powered wirelessly, and the bidirectional data telemetry is realized through the same pair of coils in 13.56 MHz. The downlink data rate is 211 Kb/s with the binary phase-shift keying (BPSK) modulation and a new BPSK demodulator. The uplink data rate is 106 Kb/s with the load-shift keying (LSK) modulation. The proposed SoC is fabricated in a 0.18-mu m CMOS technology and occupies 25 mm(2). Electrical tests have been performed to characterize the SoC performance. In vivo animal experiments using mini-pigs have been performed to successfully verify the closed-loop neuromodulation functions on epileptic seizure suppression.en_US
dc.language.isoen_USen_US
dc.subjectClosed-loop seizure controlen_US
dc.subjectlow-noise neural-signal amplifieren_US
dc.subjectneuromodulation system-on-chip (SoC)en_US
dc.subjectwireless bidirectional data telemetryen_US
dc.subjectwireless power transmissionen_US
dc.titleA Fully Integrated 16-Channel Closed-Loop Neural-Prosthetic CMOS SoC With Wireless Power and Bidirectional Data Telemetry for Real-Time Efficient Human Epileptic Seizure Controlen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/JSSC.2018.2867293en_US
dc.identifier.journalIEEE JOURNAL OF SOLID-STATE CIRCUITSen_US
dc.citation.volume53en_US
dc.citation.spage3314en_US
dc.citation.epage3326en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.department生醫電子轉譯研究中心zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.contributor.departmentBiomedical Electronics Translational Research Centeren_US
dc.identifier.wosnumberWOS:000449108400027en_US
dc.citation.woscount0en_US
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