標題: Improvement of bone-tendon fixation by porous titanium interference screw: A rabbit animal model
作者: Tsai, Pei-I
Chen, Chih-Yu
Huang, Shu-Wei
Yang, Kuo-Yi
Lin, Tzu-Hung
Chen, San-Yuan
Sun, Jui-Sheng
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: bone-tendon interface;animal studies;interference screw;additive manufacturing;Ti-alloy implants
公開日期: 1-Oct-2018
摘要: The interference screw is a widely used fixation device in the anterior cruciate ligament (ACL) reconstruction surgeries. Despite the generally satisfactory results, problems of using interference screws were reported. By using additive manufacturing (AM) technology, we developed an innovative titanium alloy (Ti6Al4V) interference screw with rough surface and inter-connected porous structure designs to improve the bone-tendon fixation. An innovative Ti6Al4V interference screws were manufactured by AM technology. In vitro mechanical tests were performed to validate its mechanical properties. Twenty-seven New Zealand white rabbits were randomly divided into control and AM screw groups for biomechanical analyses and histological analysis at 4, 8, and 12 weeks postoperatively; while micro-CT analysis was performed at 12 weeks postoperatively. The biomechanical tests showed that the ultimate failure load in the AM interference screw group was significantly higher than that in the control group at all tested periods. These results were also compatible with the findings of micro-CT and histological analyses. In micro-CT analysis, the bone-screw gap was larger in the control group; while for the additive manufactured screw, the screw and bone growth was in close contact. In histological study, the bone-screw gaps were wider in the control group and were almost invisible in the AM screw group. The innovative AM interference screws with surface roughness and inter-connected porous architectures demonstrated better bone-tendon-implant integration, and resulted in stronger biomechanical characteristics when compared to traditional screws. These advantages can be transferred to future interference screw designs to improve their clinical performance. The AM interference screw could improve graft fixation and eventually result in better biomechanical performance of the bone-tendon-screw construct. The innovative AM interference screws can be transferred to future interference screw designs to improve the performance of implants. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2633-2640, 2018.
URI: http://dx.doi.org/10.1002/jor.24037
http://hdl.handle.net/11536/148420
ISSN: 0736-0266
DOI: 10.1002/jor.24037
期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
Volume: 36
起始頁: 2633
結束頁: 2640
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