標題: The clonic phase of seizures in patients treated with electroconvulsive therapy is related to age and stimulus intensity
作者: Wang, Chao-Chih
Lin, Ching-Hung
Chiu, Yao-Chu
Tseng, Chih-Chieh
生醫電子轉譯研究中心
Biomedical Electronics Translational Research Center
關鍵字: seizure duration;tonic phase;clonic phase;age;electroconvulsive therapy
公開日期: 23-Dec-2013
摘要: Background: Electroconvulsive therapy (ECT) is effective in the treatment of major depressive disorder and schizophrenia in patients who are drug-naive or less-receptive to antipsychotic drugs. Several studies have discussed the correlation between patient characteristics, input-current volume, and seizure duration. According to the present principle of ECT guidelines, the therapeutic effect of ECT mostly correlates with seizure duration. As the tonic phase is different from the clonic phase with respect to brain function and activity, it is informative to analyze both the tonic and clonic phases. Thus, this study sought to clarify the relationship between the features of the two phases, and to re-examine and refine guidelines regarding ECT treatment. Method: ECT-course data from 44 schizophrenia or bipolar I patients were recollected, including the number of treatments that they had received, their gender, age, and the association of these characteristics with motor seizure duration was analyzed. A two-factor correlation was employed to test the relationship between each of the two factors. Result: The post-analysis results indicate that seizure duration and age are significantly correlated. Older patients had relatively short seizure durations after ECT-treatment. Notably, a negative correlation was only found between age and the clonic phase of the seizure, not between age and the tonic phase. Furthermore, this study also found an inverse relationship between ECT-intensity and the clonic phase, but not between ECT-intensity and the tonic phase. Conclusion: This study demonstrated that age and ECT-intensity are negatively correlated with seizure duration, particularly in the clonic phase. The present observations are not fully consistent with the basic guidelines of the APA-ECT practical manual. Accordingly, the predictions regarding the therapeutic effect of ECT can be based on both the seizure duration and the clonic phase.
URI: http://dx.doi.org/10.3389/fpsyt.2013.00166
http://hdl.handle.net/11536/148428
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2013.00166
期刊: FRONTIERS IN PSYCHIATRY
Volume: 4
起始頁: 0
結束頁: 0
Appears in Collections:Articles


Files in This Item:

  1. 1e394763127251606047bec9f4622625.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.