標題: Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching
作者: Tsai, Wei-Kai
Wang, Chun-I.
Liao, Chia-Hsien
Yao, Chun-Nien
Kuo, Tsai-Jhen
Liu, Ming-Ho
Hsu, Chao-Ping
Lin, Shu-Yi
Wu, Chang-Yi
Pyle, Joseph R.
Chen, Jixin
Chan, Yang-Hsiang
應用化學系
Department of Applied Chemistry
公開日期: 7-Jan-2019
摘要: Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system. The fluorescence quantum yield of anti-ACQ-based Pdots can be over 50% and the average per-particle brightness of the Pdots is about 5 times higher than that of the commercially available quantum dots. To help understand why the monomer conformations could greatly affect the optical properties of Pdots, molecular dynamics simulations were performed for the first time in such complicated Pdot systems. To demonstrate applications for in vivo fluorescence imaging, both microangiography imaging on living zebrafish embryos and specific tumor targeting on mice were performed. We anticipate that these studies will pave the way for the design of new highly fluorescent Pdot systems.
URI: http://dx.doi.org/10.1039/c8sc03510e
http://hdl.handle.net/11536/148671
ISSN: 2041-6520
DOI: 10.1039/c8sc03510e
期刊: CHEMICAL SCIENCE
Volume: 10
起始頁: 198
結束頁: 207
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