標題: Programmable flow rate scanner for evaluating detector sensitivity regime
作者: Prabhu, Gurpur Rakesh D.
Witek, Henryk A.
Urban, Pawel L.
交大名義發表
應用化學系
National Chiao Tung University
Department of Applied Chemistry
關鍵字: Automation;Flow rate;Mass spectrometry;Optimization;Prototype;Sensitivity
公開日期: 1-Mar-2019
摘要: In order to expedite characterization of on-line detection systems, we have developed a flow rate scanner comprising a pump, an inexpensive single-board computer, and an associated Python program. The program controls the pump, triggers the detector, acquires raw data, filters/smooths the data, calculates the first derivative of the temporal signal trend, and determines the sensitivity regime threshold in real time. The slope of the curve relating the detector response with the sample flow rate is used to determine the sensitivity regime for a given analyte and a given detector. The key part of the data analysis is on-the-fly calculation of the first derivatives using a fourth-order polynomial fit to the raw data by the Savitzky-Golay algorithm. The device has been tested by determining the flow rate profiles for an ultraviolet absorption detector and a mass spectrometer operated with electrospray ionization, atmospheric pressure chemical ionization, and a dual ion source. The sensitivity regime thresholds for various test analytes have been determined automatically and robustly in time as short as a few minutes.
URI: http://dx.doi.org/10.1016/j.snb.2018.11.033
http://hdl.handle.net/11536/148687
ISSN: 0925-4005
DOI: 10.1016/j.snb.2018.11.033
期刊: SENSORS AND ACTUATORS B-CHEMICAL
Volume: 282
起始頁: 992
結束頁: 998
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