完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liao, Lun-De | en_US |
dc.contributor.author | Chen, You-Yin | en_US |
dc.contributor.author | Lin, Chin-Teng | en_US |
dc.contributor.author | Chang, Jyh-Yeong | en_US |
dc.contributor.author | Li, Meng-Lin | en_US |
dc.date.accessioned | 2014-12-08T15:20:53Z | - |
dc.date.available | 2014-12-08T15:20:53Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.isbn | 978-0-8194-8436-9 | en_US |
dc.identifier.issn | 0277-786X | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/14869 | - |
dc.identifier.uri | http://dx.doi.org/10.1117/12.874449 | en_US |
dc.description.abstract | In this study, we report on using a 50-MHz functional photoacoustic microscopy (PAM) to transcranially image the cross-section and hemoglobin oxygenation (SO(2)) changes of single mouse cortical vessels in response to left forepaw electrical stimulation. Three difference levels of the cortical vessels (i.e., with different-sized diameters of 350, 100 and 55 mu m) on activated regions were marked to measure their functional cross-section and SO(2) changes as a function of time. Electrical stimulation of the mouse left forelimb was applied to evoke functional changes in vascular dynamics of the mouse somatosensory cortex. The applied current pulses were with a pulse frequency of 3 Hz, pulse duration of 0.2 ms, and pulse amplitude of 2 mA. The cerebrovascular cross-section changes, which indicate changes in cerebral blood volume (CBV), were probed by images acquired at 570 nm, a hemoglobin isosbestic point, while SO(2) changes were monitored by the derivatives of 560-nm images normalized to 570-nm ones. The results show that vessel diameter and SO(2) were significantly dilated and increased when compared with those of the controlled ones. In summary, the PAM shows its promise as a new imaging modality for transcranially functional quantification of single vessel diameter (i.e., CBV) and SO(2) changes without any contrast agents applied during stimulation. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Functional imaging | en_US |
dc.subject | photoacoustic microscopy | en_US |
dc.subject | electrical stimulation | en_US |
dc.subject | somatosensory cortex | en_US |
dc.subject | vasodilatation | en_US |
dc.subject | hemoglobin oxygenation | en_US |
dc.title | Functional transcranial photoacoustic micro-imaging of mouse cerebrovascular cross-section and hemoglobin oxygenation changes during forepaw electrical stimulation | en_US |
dc.type | Proceedings Paper | en_US |
dc.identifier.doi | 10.1117/12.874449 | en_US |
dc.identifier.journal | PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2011 | en_US |
dc.citation.volume | 7899 | en_US |
dc.contributor.department | 電機工程學系 | zh_TW |
dc.contributor.department | Department of Electrical and Computer Engineering | en_US |
dc.identifier.wosnumber | WOS:000297633500081 | - |
顯示於類別: | 會議論文 |