標題: Reliability Hardening Mechanisms in Cyber-Physical Digital-Microfluidic Biochips
作者: Lu, Guan-Ruei
Banerjee, Ansuman
Bhattacharya, Bhargab B.
Ho, Tsung-Yi
Chen, Hung-Ming
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: Physical design automation;checkpoint;sensor;droplet routing;microfluidics;biochips
公開日期: 1-Oct-2018
摘要: In the area of biomedical engineering, digital-microfluidic biochips (DMFBs) have received considerable attention because of their capability of providing an efficient and reliable platform for conducting point-of-care clinical diagnostics. System reliability, in turn, mandates error-recoverability while implementing biochemical assays on-chip for medical applications. Unfortunately, the technology of DMFBs is not yet fully equipped to handle error-recovery from various microfluidic operations involving droplet motion and reaction. Recently, a number of cyber-physical systems have been proposed to provide real-time checking and error-recovery in assays based on the feedback received from a few on-chip checkpoints. However, to synthesize robust feedback systems for different types of DMFBs, certain practical issues need to be considered such as co-optimization of checkpoint placement, error-recoverability, and layout of droplet-routing pathways. For application-specific DMFBs, we propose here an algorithm that minimizes the number of checkpoints and determines their locations to cover every path in a given droplet-routing solution. Next, for general-purpose DMFBs, where the checkpoints are pre-deployed in specific locations, we present a checkpoint-aware routing algorithm such that every droplet-routing path passes through at least one checkpoint to enable error-recovery and to ensure physical routability of all droplets. Furthermore, we also propose strategies for executing the algorithms in reliable mode to enhance error-recoverability. The proposed methods thus provide reliability-hardening mechanisms for a wide class of cyber-physical DMFBs.
URI: http://dx.doi.org/10.1145/3229052
http://hdl.handle.net/11536/148789
ISSN: 1550-4832
DOI: 10.1145/3229052
期刊: ACM JOURNAL ON EMERGING TECHNOLOGIES IN COMPUTING SYSTEMS
Volume: 14
Appears in Collections:Articles