標題: | Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting |
作者: | Lin, Chih-Ming Liu, Chi-Kuang Chang, Yu-Jun Chen, Wei-Liang Lu, Henry Horng-Shing 統計學研究所 大數據研究中心 Institute of Statistics Big Data Res Ctr |
關鍵字: | Ischemic stroke;ophthalmic artery;modified Rankin scale;Barthel Index;C-reactive protein;carotid duplex |
公開日期: | 1-一月-2019 |
摘要: | Stroke is the leading cause of death worldwide and stenosis of the carotid artery accounts for more than half of all cases. Carotid duplex is an effective non-invasive ultrasound test which identifies stroke patients with moderate to severe carotid stenosis who are candidates for preventative intervention to reduce the risk of recurrence. In patients with moderate to severe carotid stenosis, reversed ophthalmic artery flow (ROAF) is often observed at the time of the carotid duplex scan. In this study, we investigated whether ROAF, denoting exhaustion of cerebral collateral flow in ischemic stroke patients affected mid-term functional outcomes following carotid artery stenting (CAS) procedures. In total, 144 consecutive patients with a first episode of ischemic stroke and subsequent CAS procedure conducted between January 2010 and November 2014 at Changhua Christian Hospital, Taiwan were included. Clinical data were obtained by medical record review. Disability was assessed at two time points by utilising the Barthel Index (BI) and modified Rankin Scale (mRS) before CAS and 12 months post-CAS. Among 85 patients presenting without ROAF, 48/85 (56.4%) had improved mRS scores following stenting. The condition remained unchanged (stationary) in 36/85 (43.3%) patients after stenting and one patient exhibited deteriorated condition 1/85(1.1%). In contrast, among the 59 patients presenting with ROAF, 24/59 (40.6%) had improved mRS score following stenting. The condition remained unchanged (stationary) in the remaining 35/59 (59.3%) patients after stenting, and no patient exhibited deteriorated condition 0/ 59 (0 %). This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group. |
URI: | http://dx.doi.org/10.1080/01616412.2018.1544744 http://hdl.handle.net/11536/148912 |
ISSN: | 0161-6412 |
DOI: | 10.1080/01616412.2018.1544744 |
期刊: | NEUROLOGICAL RESEARCH |
Volume: | 41 |
起始頁: | 132 |
結束頁: | 138 |
顯示於類別: | 期刊論文 |