標題: One-pot synthesis of 4-arylidene imidazolin-5-ones by reaction of amino acid esters with isocyanates and alpha-bromoketones
作者: Haung, Jia-Yun
Barve, Indrajeet J.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 21-三月-2019
摘要: A simple and new multicomponent reaction for the one-pot synthesis of substituted 4-arylidene imidazolin- 5-ones from L-amino acid methyl esters, iso-, isothio-or isoselenocyanates, and alpha-bromoketones is demonstrated. Isolation of thiohydantoin and 5-benzylidene 2-thioxoimidazolidin-4-one intermediates revealed a possible reaction mechanism. The strategy was further extended to the synthesis of 2-iminothiazolines and 2-thioxoimidazolin-4-ones.
URI: http://dx.doi.org/10.1039/c8ob03111h
http://hdl.handle.net/11536/149019
ISSN: 1477-0520
DOI: 10.1039/c8ob03111h
期刊: ORGANIC & BIOMOLECULAR CHEMISTRY
Volume: 17
起始頁: 3040
結束頁: 3047
顯示於類別:期刊論文