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dc.contributor.authorBarve, Indrajeet J.en_US
dc.contributor.authorChang, Wong-Jinen_US
dc.contributor.authorLin, Yen-Tzuen_US
dc.contributor.authorThikekar, Tushar Ulhasen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2019-05-02T00:25:59Z-
dc.date.available2019-05-02T00:25:59Z-
dc.date.issued2019-04-01en_US
dc.identifier.issn2156-8952en_US
dc.identifier.urihttp://dx.doi.org/10.1021/acscombsci.8b00152en_US
dc.identifier.urihttp://hdl.handle.net/11536/151702-
dc.description.abstractBase-controlled regioselective synthesis of 2-imino thiazolines and 2-thioxoimidazolin-4-ones was achieved to use a one-pot reaction between chiral amino esters, isothiocyanates, and alpha-bromoketones/alkyl halides. This three-component coupling reaction in acetonitrile provides 2-imino thiazolines, whereas the formation of 2-thioxoimidazolin-4-ones was observed under basic conditions at ambient temperature. The corresponding products were obtained in good to excellent yield with broad substrate scope. Isolation of thiourea and thiohydantoin intermediates disclosed the course of the reaction mechanism.en_US
dc.language.isoen_USen_US
dc.subject2-imino thiazolineen_US
dc.subjectmulticomponent reactionen_US
dc.subjectregioselective synthesisen_US
dc.subjectsingle reactant replacementen_US
dc.subject2-thioxoimidazolin-4-oneen_US
dc.titleBase Controlled Three-Component Regioselective Synthesis of 2-Imino Thiazolines and 2-Thioxoimidazolin-4-onesen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/acscombsci.8b00152en_US
dc.identifier.journalACS COMBINATORIAL SCIENCEen_US
dc.citation.volume21en_US
dc.citation.issue4en_US
dc.citation.spage269en_US
dc.citation.epage275en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000464249500004en_US
dc.citation.woscount0en_US
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