標題: Membrane protein-regulated networks across human cancers
作者: Lin, Chun-Yu
Lee, Chia-Hwa
Chuang, Yi-Hsuan
Lee, Jung-Yu
Chiu, Yi-Yuan
Lee, Yan-Hwa Wu
Jong, Yuh-Jyh
Hwang, Jenn-Kang
Huangq, Sing-Han
Chen, Li-Ching
Wu, Chih-Hsiung
Tu, Shih-Hsin
Ho, Yuan-Soon
Yang, Jinn-Moon
交大名義發表
生物資訊及系統生物研究所
生醫工程研究所
National Chiao Tung University
Institude of Bioinformatics and Systems Biology
Institute of Biomedical Engineering
公開日期: 16-Jul-2019
摘要: Alterations in membrane proteins (MPs) and their regulated pathways have been established as cancer hallmarks and extensively targeted in clinical applications. However, the analysis of MP-interacting proteins and downstream pathways across human malignancies remains challenging. Here, we present a systematically integrated method to generate a resource of cancer membrane protein-regulated networks (CaMPNets), containing 63,746 high-confidence protein-protein interactions (PPIs) for 1962 MPs, using expression profiles from 5922 tumors with overall survival outcomes across 15 human cancers. Comprehensive analysis of CaMPNets links MP partner communities and regulated pathways to provide MP-based gene sets for identifying prognostic biomarkers and druggable targets. For example, we identify CHRNA9 with 12 PPIs (e.g., ERBB2) can be a therapeutic target and find its anti-metastasis agent, bupropion, for treatment in nicotine-induced breast cancer. This resource is a study to systematically integrate MP interactions, genomics, and clinical outcomes for helping illuminate cancer-wide atlas and prognostic landscapes in tumor homo/heterogeneity.
URI: http://dx.doi.org/10.1038/s41467-019-10920-8
http://hdl.handle.net/11536/152168
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10920-8
期刊: NATURE COMMUNICATIONS
Volume: 10
起始頁: 0
結束頁: 0
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