標題: Early recovery of interhemispheric functional connectivity after corpus callosotomy
作者: Hung, Sheng-Che
Lee, Cheng-Chia
Chen, Hsin-Hung
Chen, Chien
Wu, Hsiu-Mei
Lin, Ching-Po
Peng, Syu-Jyun
電子工程學系及電子研究所
生醫電子轉譯研究中心
Department of Electronics Engineering and Institute of Electronics
Biomedical Electronics Translational Research Center
關鍵字: corpus callosotomy;graph theory;interhemispheric functional connectivity;voxel-mirrored homotopic connectivity
公開日期: 1-Jun-2019
摘要: Objective To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy. Methods Eight epilepsy patients undergoing total callosotomy were recruited. Resting-state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel-mirrored homotopic connectivity (VMHC). The seizure outcome was scored using the Engel surgical outcome scale. Results After callosotomy (mean postoperative interval = 4 months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric FC and homotopic VMHC were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged. Significance The interhemispheric FC may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.
URI: http://dx.doi.org/10.1111/epi.14933
http://hdl.handle.net/11536/152221
ISSN: 0013-9580
DOI: 10.1111/epi.14933
期刊: EPILEPSIA
Volume: 60
Issue: 6
起始頁: 1126
結束頁: 1136
Appears in Collections:Articles