標題: | Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants |
作者: | Tsai, Pei-I. Lam, Tu-Ngoc Wu, Meng-Huang Tseng, Kuan-Ying Chang, Yuan-Wei Sun, Jui-Sheng Li, Yen-Yao Lee, Ming-Hsueh Chen, San-Yuan Chang, Chung-Kai Su, Chun-Jen Lin, Chia-Hsien Chiang, Ching-Yu Ku, Ching-Shun Tsou, Nien-Ti Shih, Shao-Ju Wang, Chun-Chieh Huang, E-Wen 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | Implant;Additive manufacturing;X-ray tomography;Small X-ray angle scattering;Nano X-ray Laue diffraction mapping |
公開日期: | 15-五月-2019 |
摘要: | Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti-6Al-4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti-6Al-4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti-6Al-4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti-6Al-4V pores enhance the collagen-regulated mineralization. |
URI: | http://dx.doi.org/10.1016/j.matchemphys.2019.03.047 http://hdl.handle.net/11536/152362 |
ISSN: | 0254-0584 |
DOI: | 10.1016/j.matchemphys.2019.03.047 |
期刊: | MATERIALS CHEMISTRY AND PHYSICS |
Volume: | 230 |
起始頁: | 83 |
結束頁: | 92 |
顯示於類別: | 期刊論文 |