標題: Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants
作者: Tsai, Pei-I.
Lam, Tu-Ngoc
Wu, Meng-Huang
Tseng, Kuan-Ying
Chang, Yuan-Wei
Sun, Jui-Sheng
Li, Yen-Yao
Lee, Ming-Hsueh
Chen, San-Yuan
Chang, Chung-Kai
Su, Chun-Jen
Lin, Chia-Hsien
Chiang, Ching-Yu
Ku, Ching-Shun
Tsou, Nien-Ti
Shih, Shao-Ju
Wang, Chun-Chieh
Huang, E-Wen
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Implant;Additive manufacturing;X-ray tomography;Small X-ray angle scattering;Nano X-ray Laue diffraction mapping
公開日期: 15-May-2019
摘要: Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti-6Al-4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti-6Al-4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti-6Al-4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti-6Al-4V pores enhance the collagen-regulated mineralization.
URI: http://dx.doi.org/10.1016/j.matchemphys.2019.03.047
http://hdl.handle.net/11536/152362
ISSN: 0254-0584
DOI: 10.1016/j.matchemphys.2019.03.047
期刊: MATERIALS CHEMISTRY AND PHYSICS
Volume: 230
起始頁: 83
結束頁: 92
Appears in Collections:Articles