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dc.contributor.authorChen, Li-Ruen_US
dc.contributor.authorKo, Nai-Yuen_US
dc.contributor.authorChen, Kuo-Huen_US
dc.date.accessioned2019-08-02T02:18:35Z-
dc.date.available2019-08-02T02:18:35Z-
dc.date.issued2019-05-01en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ijms20092213en_US
dc.identifier.urihttp://hdl.handle.net/11536/152389-
dc.description.abstractOsteoporosis is a major concern all over the world. With aging, a gradual loss of bone mass results in osteopenia and osteoporosis. Heritable factors account for 60-80% of optimal bone mineralization. Modifiable factors, such as weight-bearing exercise, nutrition, body mass, and hormonal milieu, play an important role in the development of osteopenia and osteoporosis in adulthood. Currently, anti-resorptive agents, including estrogen, bisphosphonates, and selective estrogen receptor modulators (SERMs), are the drugs of choice for osteoporosis. Other treatments include parathyroid hormone (PTH) as well as the nutritional support of calcium and vitamin D. New treatments such as tissue-selective estrogen receptor complexes (TSECs) are currently in use too. This review, which is based on a systematic appraisal of the current literature, provides current molecular and genetic opinions on osteoporosis and its medical treatment. It offers evidence-based information to help researchers and clinicians with osteoporosis assessment. However, many issues regarding osteoporosis and its treatment remain unknown or controversial and warrant future investigation.en_US
dc.language.isoen_USen_US
dc.subjectosteoporosisen_US
dc.subjectanti-resorptive drugsen_US
dc.subjectmolecular pathwayen_US
dc.subjectgeneticsen_US
dc.titleMedical Treatment for Osteoporosis: From Molecular to Clinical Opinionsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms20092213en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.citation.volume20en_US
dc.citation.issue9en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department機械工程學系zh_TW
dc.contributor.departmentDepartment of Mechanical Engineeringen_US
dc.identifier.wosnumberWOS:000469753500160en_US
dc.citation.woscount0en_US
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