標題: Ribavirin facilitates early viral kinetics in chronic hepatitis C patients receiving daclatasvir/asunaprevir
作者: Huang, Chung-Feng
Yeh, Ming-Lun
Huang, Ching-, I
Liang, Po-Cheng
Lin, Yi-Hun
Hsieh, Ming-Yen
Chen, Kuan-Yu
Ko, Yu-Min
Lin, Zu-Yau
Chen, Shinn-Cherng
Huang, Jee-Fu
Dai, Chia-Yen
Chuang, Wan-Long
Yu, Ming-Lung
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
關鍵字: DAA;RBV;treatment;viral kinetics
公開日期: 1-一月-1970
摘要: Background and Aim Ribavirin (RBV) remains crucial in difficult-to-cure chronic hepatitis C patients receiving directly acting antivirals (DAAs). The current study aimed to address whether RBV enhanced early viral kinetics in patients with DAAs. Methods Hepatitis C virus (HCV) genotype-1b patients were allocated to daclatasvir/asunaprevir +weight-based RBV (1000-1200 mg/day) for 12-24 weeks. HCV RNA levels were compared at day 1, week 1, week 2, and week 4 of treatment. Results The sustained virological response rate was 100% (67/67) and 96.7% (59/61) in the RBV and non-RBV group, respectively. The HCV RNA levels at treatment week 2 (W2) were significantly lower in the RBV group than in the non-RBV group (0.42 +/- 0.81 log IU/mL vs 0.79 +/- 1.03 log IU/mL, P = 0.04). Among the intermediate responders who remained to have detectable RNA after W1 of treatment, patients with RBV had a significantly higher rate of undetectable HCV RNA (71.4% vs 36.0%, P = 0.003) and lower HCV RNA level at W2 (0.55 +/- 0.89 log IU/mL vs 1.32 +/- 1.04 log IU/mL, P = 0.001). A more significant magnitude of HCV RNA reduction was also noted from baseline to day 1 (3.15 +/- 0.38 log IU/mL vs 2.80 +/- 0.70 log IU/mL, P = 0.009) and W1 to W2 (1.40 +/- 0.65 log IU/mL vs 0.88 +/- 0.78 log IU/mL, P = 0.007) in the RBV group compared to the non-RBV group among the intermediate responders. Logistic regression analysis revealed that adding RBV independently predicted undetectable HCV RNA at W2 (odds ratio/confidence interval: 4.74/1.54-14.57, P = 0.007) in the intermediate responders. Conclusions Adding RBV to DAAs improved early viral kinetic, in particular, for intermediate responders.
URI: http://dx.doi.org/10.1111/jgh.14815
http://hdl.handle.net/11536/153018
ISSN: 0815-9319
DOI: 10.1111/jgh.14815
期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
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