标题: | Iron embedded magnetic nanodiamonds for in vivo MRI contrast enhancement |
作者: | Lin, Bo-Rong Chen, Chien-Hsu Chang, Chun-Hsiang Kunuku, Srinivasu Chen, Tzung-Yuang Hsiao, Tung-Yuan Yu, Hung-Kai Chang, Yu-Jen Liao, Li-Chuan Chen, Fang-Hsin Niu, Huan Lee, Chien-Ping 电子工程学系及电子研究所 Department of Electronics Engineering and Institute of Electronics |
关键字: | iron;nanodiamonds;ion implantation;in vivo;mri;contrast enhancement |
公开日期: | 11-十二月-2019 |
摘要: | Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo magnetic resonance imaging (MRI) application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. An MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of nanodiamonds and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging. |
URI: | http://dx.doi.org/10.1088/1361-6463/ab41e8 http://hdl.handle.net/11536/153082 |
ISSN: | 0022-3727 |
DOI: | 10.1088/1361-6463/ab41e8 |
期刊: | JOURNAL OF PHYSICS D-APPLIED PHYSICS |
Volume: | 52 |
Issue: | 50 |
起始页: | 0 |
结束页: | 0 |
显示于类别: | Articles |