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dc.contributor.authorHsieh, Jason Chia-Hsunen_US
dc.contributor.authorChen, Guan-Yuen_US
dc.contributor.authorJhou, David Da-Weien_US
dc.contributor.authorChou, Wen-Chien_US
dc.contributor.authorYeh, Chun-Nanen_US
dc.contributor.authorHwang, Tsann-Longen_US
dc.contributor.authorLin, Hung-Chien_US
dc.contributor.authorChu, Hui-Chunen_US
dc.contributor.authorWang, Hung-Mingen_US
dc.contributor.authorYen, Tzu-Chenen_US
dc.contributor.authorChen, Jen-Shien_US
dc.contributor.authorWu, Min-Hsienen_US
dc.date.accessioned2020-03-02T03:23:29Z-
dc.date.available2020-03-02T03:23:29Z-
dc.date.issued2019-12-27en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-019-56539-zen_US
dc.identifier.urihttp://hdl.handle.net/11536/153761-
dc.description.abstractCirculating tumor cells (CTC) play important roles in various cancers; however, few studies have assessed their clinical utility in neuroendocrine tumors. This study aimed to prospectively evaluate the prognostic value of CTC counts in Asian patients with neuroendocrine tumors before and during anti-cancer therapy. Patients who were diagnosed with unresectable histological neuroendocrine tumors between September 2011 and September 2017 were enrolled. CTC testing was performed before and during anti-cancer therapy using a negative selection protocol. Chromogranin A levels were also assessed. Univariate and multivariate Cox's proportional hazard model with forward LR model was performed to investigate the impact of independent factors on overall survival and progression-free survival. Kaplan-Meier method with log-rank tests were used to determine the difference among different clinicopathological signatures and CTC cutoff. The baseline CTC detection rate was 94.3% (33/35). CTC counts were associated with cancer stages (I-III vs. IV, P = 0.015), liver metastasis (P = 0.026), and neuroendocrine tumor grading (P = 0.03). The median progression-free survival and overall survivals were 12.3 and 30.4 months, respectively. In multivariate Cox regression model, neuroendocrine tumors grading and baseline CTC counts were both independent prognostic factors for progression-free survival (PFS, P = 0.005 and 0.015, respectively) and overall survival (OS, P = 0.018 and 0.023, respectively). In Kaplan-Meier analysis, lower baseline chromogranin A levels were associated with longer PFS (P = 0.024). Baseline CTC counts are associated with the clinicopathologic features of neuroendocrine tumors and are an independent prognostic factor for this malignancy.en_US
dc.language.isoen_USen_US
dc.titleThe Prognostic Value of Circulating Tumor Cells in Asian Neuroendocrine Tumorsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-019-56539-zen_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume9en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000509284000004en_US
dc.citation.woscount0en_US
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