標題: Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons
作者: Chang, Chu-Yuan
Hung, Jui-Hung
Huang, Liang-Wei
Li, Joye
Fung, Ka Shing
Kao, Cheng-Fu
Chen, Linyi
資訊工程學系
Department of Computer Science
關鍵字: enhancer regulation;histone modification;neuronal regeneration;epigenome;transcriptional regulation;WNT3A
公開日期: 1-三月-2020
摘要: Traumatic brain injury is known to reprogram the epigenome. Chromatin immunoprecipitation-sequencing of histone H3 lysine 27 acetylation (H3K27ac) and tri-methylation of histone H3 at lysine 4 (H3K4me3) marks was performed to address the transcriptional regulation of candidate regeneration-associated genes. In this study, we identify a novel enhancer region for induced WNT3A transcription during regeneration of injured cortical neurons. We further demonstrated an increased mono-methylation of histone H3 at lysine 4 (H3K4me1) modification at this enhancer concomitant with a topological interaction between sub-regions of this enhancer and with promoter of WNT3A gene. Together, this study reports a novel mechanism for WNT3A gene transcription and reveals a potential therapeutic intervention for neuronal regeneration.
URI: http://dx.doi.org/10.3390/ijms21051891
http://hdl.handle.net/11536/154104
DOI: 10.3390/ijms21051891
期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 21
Issue: 5
起始頁: 0
結束頁: 0
顯示於類別:期刊論文