標題: Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG)
作者: Kusayama, Takashi
Wong, Johnson
Liu, Xiao
He, Wenbo
Doytchinova, Anisiia
Robinson, Eric A.
Adams, David E.
Chen, Lan S.
Lin, Shien-Fong
Davoren, Katherine
Victor, Ronald G.
Cai, Cheng
Dai, Ming-Yan
Tian, Ying
Zhang, Pei
Ernst, Dereen
Rho, Richard H.
Chen, Minglong
Cha, Yong-Mei
Walega, David R.
Everett, Thomas H.
Chen, Peng-Sheng
分子醫學與生物工程研究所
Institute of Molecular Medicine and Bioengineering
公開日期: 1-May-2020
摘要: neuECG is the simultaneous noninvasive recording of ECG and skin sympathetic nerve activity and thus can directly record sympathetic nerve activity over a long period of time without the need for invasive procedures. neuECG, the simultaneous noninvasive recording of ECG and skin sympathetic nerve activity (SKNA), directly records sympathetic nerve activity over a long period of time. It can be used to measure sympathetic tone in healthy subjects and in subjects with non-cardiovascular diseases. The electrical activity that can be measured on the surface of the skin originates from the heart, the muscle or nerve structures. Because the frequency content of nerve activity falls in a higher frequency range than that of the ECG and myopotential, it is possible to use high-pass or band-pass filtering to specifically isolate the SKNA. neuECG is voltage calibrated and does not require invasive procedures to impale electrodes in nerves and thus has advantages over microneurography. Here, we present a protocol that takes <10 min to set up. The neuECG can be continuously recorded over a 24-h period or longer. We also describe methods to efficiently analyze neuECG from humans using commercially available hardware and software to facilitate adoption of this technology in clinical research.
URI: http://dx.doi.org/10.1038/s41596-020-0316-6
http://hdl.handle.net/11536/154405
ISSN: 1754-2189
DOI: 10.1038/s41596-020-0316-6
期刊: NATURE PROTOCOLS
Volume: 15
Issue: 5
起始頁: 1853
結束頁: 1877
Appears in Collections:Articles