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dc.contributor.authorLin, Hsiu-Penen_US
dc.contributor.authorAkimoto, Junen_US
dc.contributor.authorLi, Yaw-Kuenen_US
dc.contributor.authorIto, Yoshihiroen_US
dc.date.accessioned2020-07-01T05:21:22Z-
dc.date.available2020-07-01T05:21:22Z-
dc.date.issued1970-01-01en_US
dc.identifier.issn1616-5187en_US
dc.identifier.urihttp://dx.doi.org/10.1002/mabi.202000049en_US
dc.identifier.urihttp://hdl.handle.net/11536/154444-
dc.description.abstractCationic polymers exhibit high cytotoxicity via strong interaction with cell membranes. To reduce cell membrane damage, a hydrophilic polymer is introduced to the cationic nanoparticle surface. The hydrophilic polymer coating of cationic nanoparticles resulted in a nearly neutral nanoparticle. These particles are applied to mouse fibroblast (3T3) and human cervical adenocarcinoma (Hela) cells. Interestingly, nanoparticles with a long cationic segment decrease cell activity regardless of cell type, while those with a short segment only affect 3T3 cell activity at lower concentrations less than 500 mu g mL(-1). Most nanoparticles are located inside 3T3 cells but on the cell membrane of Hela cells. The short cationic nanoparticle shows negligible cell membrane damage despite its high accumulation on Hela cell membranes. Cell activity changed by hydrophilic polymer-coated cationic nanoparticles is caused by incorporated nanoparticle accumulation in the cells, not cell membrane damage. To suppress the cytotoxicity from the cationic polymer, cationic nanoparticle needs to completely cover with hydrophilic polymer so as not to exhibit the cationic effect and applies to cell with low concentrations to reduce the nonselective cytotoxicity from the cationic polymer.en_US
dc.language.isoen_USen_US
dc.subjectcationic polymersen_US
dc.subjectcellular membranesen_US
dc.subjectcytotoxicityen_US
dc.subjecthydrophilic polymer coatingen_US
dc.subjectnanoparticlesen_US
dc.titleSelective Control of Cell Activity with Hydrophilic Polymer-Covered Cationic Nanoparticlesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/mabi.202000049en_US
dc.identifier.journalMACROMOLECULAR BIOSCIENCEen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000529087700001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles