標題: Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
作者: Ku, Jason T.
Chen, Arvin Y.
Lan, Ethan I.
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: acetyl-CoA;metabolic bypass;pyruvate dehydrogenase;coenzyme A
公開日期: 1-Apr-2020
摘要: Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates.
URI: http://dx.doi.org/10.3390/metabo10040166
http://hdl.handle.net/11536/154501
DOI: 10.3390/metabo10040166
期刊: METABOLITES
Volume: 10
Issue: 4
起始頁: 0
結束頁: 0
Appears in Collections:Articles