標題: Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone-Tendon Healing: A Rabbit Animal Model
作者: Huang, Yu-Min
Huang, Chih-Chieh
Tsai, Pei-I
Yang, Kuo-Yi
Huang, Shin-I
Shen, Hsin-Hsin
Lai, Hong-Jen
Huang, Shu-Wei
Chen, San-Yuan
Lin, Feng-Huei
Chen, Chih-Yu
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: bioactive ceramic coating;interference screw;additive manufacturing;titanium-alloy implant
公開日期: 1-May-2020
摘要: The interference screw fixation method is used to secure a graft in the tibial tunnel during anterior cruciate ligament reconstruction surgery. However, several complications have been reported, such as biodegradable screw breakage, inflammatory or foreign body reaction, tunnel enlargement, and delayed graft healing. Using additive manufacturing (AM) technology, we developed a titanium alloy (Ti6Al4V) interference screw with chemically calcium phosphate surface modification technology to improve bone integration in the tibial tunnel. After chemical and heat treatment, the titanium screw formed a dense apatite layer on the metal surface in simulated body fluid. Twenty-seven New Zealand white rabbits were randomly divided into control and additive manufactured (AMD) screw groups. The long digital extensor tendon was detached and translated into a tibial plateau tunnel (diameter: 2.0 mm) and transfixed with an interference screw while the paw was in dorsiflexion. Biomechanical analyses, histological analyses, and an imaging study were performed at 1, 3, and 6 months. The biomechanical test showed that the ultimate pull-out load failure was significantly higher in the AMD screw group in all tested periods. Micro-computed tomography analyses revealed early woven bone formation in the AMD screw group at 1 and 3 months. In conclusion, AMD screws with bioactive surface modification improved bone ingrowth and enhanced biomechanical performance in a rabbit model.
URI: http://dx.doi.org/10.3390/ijms21103628
http://hdl.handle.net/11536/154980
DOI: 10.3390/ijms21103628
期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 21
Issue: 10
起始頁: 0
結束頁: 0
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