標題: A stochastic programming model of vaccine preparation and administration for seasonal influenza interventions
作者: Chen, Sheng-I
Wu, Chia-Yuan
工業工程與管理學系
Department of Industrial Engineering and Management
關鍵字: seasonal influenza;vaccination activities;stochastic integer programming;sample-average approximation
公開日期: 1-Jan-2020
摘要: This study considers the integration of vaccine preparation and administration decisions for seasonal influenza interventions. We examine actual vaccination activities of sharing multiple vaccine products and supplementary vaccinations. A two-stage stochastic program is formulated to determine the optimal ordering and allocation of vaccines under uncertain attack rates, vaccine efficacies, and demands. We present an algorithm based on the sample average approximation and warm-start solution to solve the stochastic integer program with continuous random variables. Furthermore, the optimal solution for the deterministic model using the expected value is analyzed and obtained directly. Our analysis compares the deterministic and stochastic solutions to assess the impact of uncertainties on the immunization outcomes and costs. The result shows that the stochastic programming model provides a more robust solution than the deterministic model, and uncertain characteristics should consider when making public health decisions.
URI: http://dx.doi.org/10.3934/mbe.2020169
http://hdl.handle.net/11536/155403
ISSN: 1547-1063
DOI: 10.3934/mbe.2020169
期刊: MATHEMATICAL BIOSCIENCES AND ENGINEERING
Volume: 17
Issue: 4
起始頁: 2984
結束頁: 2997
Appears in Collections:Articles