標題: Multifunctional Nanocapsules for Simultaneous Encapsulation of Hydrophilic and Hydrophobic Compounds and On-Demand Release
作者: Hu, Shang-Hsiu
Chen, San-Yuan
Gao, Xiaohu
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: nanocapsule;drug encapsulation;multifunctional;targeted;controlled release
公開日期: 1-Mar-2012
摘要: Cocktail therapy by delivering multiple drugs to diseased cells can elicit synergistic therapeutic effects and better modulate the complex cell-signaling network. Besides selection of drug combinations, a difficulty in delivery is how to encapsulate drugs with various solubility into a common vehicle, particularly when both hydrophobic and hydrophilic compounds are involved. Furthermore, it is highly desirable that the drug release profile can be controlled in an on-demand fashion for balanced therapeutic and side effects. On the basis of a simple and scalable double emulsion approach, we report a new class of nanocapsules that can solve these problems simultaneously. Further linking the nanocapsules with peptides targeting cell surface integrins leads to significantly enhanced cell uptake of the nanocapsules. Intracellular drug release triggered by external stimuli has also been achieved without affecting cell viability. Further development of this technology should open exciting opportunities in treating tough diseases such as cancer, cardiovascular diseases, neurological disorders, and infectious diseases.
URI: http://dx.doi.org/10.1021/nn205023w
http://hdl.handle.net/11536/15822
ISSN: 1936-0851
DOI: 10.1021/nn205023w
期刊: ACS NANO
Volume: 6
Issue: 3
起始頁: 2558
結束頁: 2565
Appears in Collections:Articles


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