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dc.contributor.authorHsu, Shiou-Chihen_US
dc.contributor.authorChang, Chih-Pengen_US
dc.contributor.authorTsai, Chao-Yuanen_US
dc.contributor.authorHsieh, Shih-Hungen_US
dc.contributor.authorWu-Hsieh, Betty A.en_US
dc.contributor.authorLo, Yu-Shuen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.date.accessioned2014-12-08T15:22:34Z-
dc.date.available2014-12-08T15:22:34Z-
dc.date.issued2012-06-01en_US
dc.identifier.issn0019-2805en_US
dc.identifier.urihttp://hdl.handle.net/11536/15966-
dc.description.abstractMHC class I-restricted CD8 T-lymphocyte epitopes comprise anchor motifs, T-cell receptor (TCR) contact residues and the peptide backbone. Serial variant epitopes with substitution of amino acids at either anchor motifs or TCR contact residues have been synthesized for specific interferon-? responses to clarify the TCR recognition mechanism as well as to assess the epitope prediction capacity of immunoinformatical programmes. CD8 T lymphocytes recognise the steric configuration of functional groups at the TCR contact side chain with a parallel observation that peptide backbones of various epitopes adapt to the conserved conformation upon binding to the same MHC class I molecule. Variant epitopes with amino acid substitutions at the TCR contact site are not recognised by specific CD8 T lymphocytes without compromising their binding capacity to MHC class I molecules, which demonstrates two discrete antigen presentation events for the binding of peptides to MHC class I molecules and for TCR recognition. The predicted outcome of immunoinformatical programmes is not consistent with the results of epitope identification by laboratory experiments in the absence of information on the interaction with TCR contact residues. Immunoinformatical programmes based on the binding affinity to MHC class I molecules are not sufficient for the accurate prediction of CD8 T-lymphocyte epitopes. The predictive capacity is further improved to distinguish mutant epitopes from the non-mutated epitopes if the peptideTCR interface is integrated into the computing simulation programme.en_US
dc.language.isoen_USen_US
dc.subjectCD8en_US
dc.subjectcytotoxic T cellsen_US
dc.subjectmajor histocompatibility complexesen_US
dc.subjectHLAen_US
dc.subjectT-cell receptoren_US
dc.subjectT cellsen_US
dc.subjectvaccinesen_US
dc.titleSteric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmesen_US
dc.typeArticleen_US
dc.identifier.journalIMMUNOLOGYen_US
dc.citation.volume136en_US
dc.citation.issue2en_US
dc.citation.epage139en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.identifier.wosnumberWOS:000303114300004-
dc.citation.woscount1-
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