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dc.contributor.authorHwang, Chia-Hsiangen_US
dc.contributor.authorLin, Yu-Lingen_US
dc.contributor.authorLiu, Yen-Kuen_US
dc.contributor.authorChen, Chia-Hungen_US
dc.contributor.authorWu, Hsin-Yien_US
dc.contributor.authorChang, Cheng-Changen_US
dc.contributor.authorChang, Chao-Yuanen_US
dc.contributor.authorChang, Yu-Kuoen_US
dc.contributor.authorChiu, Yi-Hanen_US
dc.contributor.authorLiao, Kuang-Wenen_US
dc.contributor.authorLai, Yiu-Kayen_US
dc.date.accessioned2014-12-08T15:22:49Z-
dc.date.available2014-12-08T15:22:49Z-
dc.date.issued2012-04-01en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.urihttp://hdl.handle.net/11536/16103-
dc.description.abstract7,7''-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from the needles of Taxus X media cv. Hicksii, was evaluated for its antiproliferative and antineoplastic effects in three human cancer cell lines. Interestingly, DMGF caused cell death via different pathways in different cancer cells. DMGF induced apoptosis, activated caspase-3 activity and changed the mitochondrial membrane potential in HT-29 human colon cancer cells. However, the apoptotic pathway is not the major pathway involved in DMGF-induced cell death in A549 human lung cancer cells and HepG2 human hepatoma cells. Treatment with 3-MA, an inhibitor of autophagy, significantly decreased DMGF-induced cell death in HepG2 and A549 cells, but did not affect DMGF-induced cell death in HT-29 cells. Following DMGF treatment, the HepG2 cells increased expression of LC3B-II, a marker used to monitor autophagy in cells. Thus, DMGF induced apoptotic cell death in HT-29 cells, triggered both apoptotic and autophagic death in A549 cells and induced autophagic cell death in HepG2 cells. Copyright (C) 2011 John Wiley & Sons, Ltd.en_US
dc.language.isoen_USen_US
dc.subject7en_US
dc.subject7 ''-dimethoxyagastisflavoneen_US
dc.subjectbiflavonoiden_US
dc.subjectTaxus media cven_US
dc.subjectHicksiien_US
dc.subjectapoptosisen_US
dc.subjectautophagyen_US
dc.title7,7 ''-Dimethoxyagastisflavone-induced Apoptotic or Autophagic Cell Death in Different Cancer Cellsen_US
dc.typeArticleen_US
dc.identifier.journalPHYTOTHERAPY RESEARCHen_US
dc.citation.volume26en_US
dc.citation.issue4en_US
dc.citation.epage528en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000302620000009-
dc.citation.woscount5-
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