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dc.contributor.authorChen, Chia-Hungen_US
dc.contributor.authorLin, Yu-Lingen_US
dc.contributor.authorLiu, Yen-Kuen_US
dc.contributor.authorHe, Pei-Juinen_US
dc.contributor.authorLin, Ching-Minen_US
dc.contributor.authorChiu, Yi-Hanen_US
dc.contributor.authorWu, Chang-Jeren_US
dc.contributor.authorCheng, Tian-Luen_US
dc.contributor.authorLiu, Shih-Jenen_US
dc.contributor.authorLiao, Kuang-Wenen_US
dc.date.accessioned2014-12-08T15:23:02Z-
dc.date.available2014-12-08T15:23:02Z-
dc.date.issued2012en_US
dc.identifier.issn1178-2013en_US
dc.identifier.urihttp://hdl.handle.net/11536/16195-
dc.description.abstractThe aim of vaccination is to induce appropriate immunity against pathogens. Antibody-mediated immunity is critical for protection against many virus diseases, although it is becoming more evident that coordinated, multifunctional immune responses lead to the most effective defense. Specific antibody (Ab) isotypes are more efficient at protecting against pathogen invasion in different locations in the body. For example, compared to other Ab isotypes, immunoglobulin (Ig) A provides more protection at mucosal areas. In this study, we developed a cationic lipopolymer (liposome-polyethylene glycol-polyethyleneimine complex [LPPC])-adjuvant that strongly adsorbs antigens or immunomodulators onto its surface to enhance or switch immune responses. The results demonstrate that LPPC enhances uptake ability, surface marker expression, proinflammatory cytokine release, and antigen presentation in mouse-phagocytes. In contrast to Freund's adjuvant, LPPC preferentially activates-Th1-immunity against antigens in vivo. With lipopolysaccharides or CpG oligodeoxynucleotides, LPPC dramatically enhances the IgA or IgG2A proportion of total Ig, even in hosts that have developed Th2 immunities and high IgG1 serum titers. Taken together, the results demonstrate that the LPPC adjuvant not only increases the immunogenicity of antigens but also modulates host immunity to produce an appropriate Ab isotype by combining with immunomodulators.en_US
dc.language.isoen_USen_US
dc.subjectliposome-PEG-PEI complexen_US
dc.subjectadjuvanten_US
dc.subjectclass switchen_US
dc.subjectimmunomodulatoren_US
dc.subjectvaccineen_US
dc.titleLiposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switchen_US
dc.typeArticleen_US
dc.identifier.journalINTERNATIONAL JOURNAL OF NANOMEDICINEen_US
dc.citation.volume7en_US
dc.citation.epage607en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000302712700001-
dc.citation.woscount4-
Appears in Collections:Articles


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