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dc.contributor.authorTseng, Chih-Chungen_US
dc.contributor.authorTasi, Cheng-Hsunen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:23:13Z-
dc.date.available2014-12-08T15:23:13Z-
dc.date.issued2012-06-01en_US
dc.identifier.issn1386-2073en_US
dc.identifier.urihttp://hdl.handle.net/11536/16294-
dc.description.abstractA novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.en_US
dc.language.isoen_USen_US
dc.subjectBenzimidazolesen_US
dc.subjectbioactive heterocyclesen_US
dc.subjectfluorous synthesisen_US
dc.subjectF-SPEen_US
dc.subjectmicrowave chemistryen_US
dc.titleLight Fluorous-Tagged Traceless One-Pot Synthesis of Benzimidazoles Facilitated by Microwave Irradiationen_US
dc.typeArticleen_US
dc.identifier.journalCOMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENINGen_US
dc.citation.volume15en_US
dc.citation.issue5en_US
dc.citation.epage411en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000304043600006-
dc.citation.woscount2-
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