標題: Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
作者: Chen, Yu-Shiun
Hung, Yao-Ching
Hong, Meng-Yeng
Onischuk, Andrei Aleksandrovich
Chiou, Jin Chern
Sorokina, Irina V.
Tolstikova, Tatiana
Huang, G. Steve
材料科學與工程學系
電控工程研究所
Department of Materials Science and Engineering
Institute of Electrical and Control Engineering
公開日期: 2012
摘要: "Nanoparticles are unfamiliar to researchers in toxicology. Toxicity may be generated simply due to the reduction in size. Compounds that prevent or cure toxic materials may not work on nanoparticles. Furthermore, as there are more and more applications of nanoparticles in drug delivery and in vivo imaging, controlling the transport and toxicity will be primary concerns for medical application of nanoparticles. Gold nanoparticles (GNPs) if injected intraperitoneally into mice can enter hippocampus and induce cognitive impairment. GNPs caused a global imbalance of monoamine levels, specifically affecting the dopaminergic and serotonergic neurons. Pretreatment of tea melanin significantly prevented the deposition of GNPs in mouse brains, especially in the hippocampus. Pretreatment of melanin completely alleviated GNP-induced impairment of cognition. Pre-administration of melanin stably maintained monoamines at normal profiles. Melanin completely prevented the invasion of GNPs into the Cornu Ammonis region of the hippocampus shown by coherent anti-Stoke Raman scattering microscopy. Here we show that the administration of tea melanin prevented the accumulation of Au in brain, the imbalance of monoamines, and the impairment of cognition in mice. The current study provides a therapeutic approach to toxicity of nanoparticles and a novel strategy to control the transport of GNP in mouse brain."
URI: http://hdl.handle.net/11536/16672
http://dx.doi.org/746960
ISSN: 1687-4110
DOI: 746960
期刊: JOURNAL OF NANOMATERIALS
顯示於類別:期刊論文


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