標題: | Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas |
作者: | Chung, Tsai-Wen Chen, Chih-Hau Lin, Chu-Chung Wu, Hsien-Jen Sun, Chung-Ming Chung, Wen-Sheng 應用化學系 Department of Applied Chemistry |
關鍵字: | Trimethyl aluminum;Traceless;Solid-phase synthesis;Sulfone linker;Sulfinate-functionalized resin;Sulfonamides;Ureas |
公開日期: | 1-八月-2012 |
摘要: | A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed. |
URI: | http://dx.doi.org/10.1007/s11030-012-9380-3 http://hdl.handle.net/11536/16915 |
ISSN: | 1381-1991 |
DOI: | 10.1007/s11030-012-9380-3 |
期刊: | MOLECULAR DIVERSITY |
Volume: | 16 |
Issue: | 3 |
起始頁: | 463 |
結束頁: | 476 |
顯示於類別: | 期刊論文 |