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dc.contributor.authorChuang, Ching-Chengen_US
dc.contributor.authorChen, Chung-Mingen_US
dc.contributor.authorHsieh, Yao-Shengen_US
dc.contributor.authorLiu, Tsan-Chien_US
dc.contributor.authorSun, Chia-Weien_US
dc.date.accessioned2014-12-08T15:29:24Z-
dc.date.available2014-12-08T15:29:24Z-
dc.date.issued2013-03-01en_US
dc.identifier.issn1864-063Xen_US
dc.identifier.urihttp://dx.doi.org/10.1002/jbio.201200025en_US
dc.identifier.urihttp://hdl.handle.net/11536/21181-
dc.description.abstractThe goal of this study is to prove that the light propagation in the head by used the 3-D optical model from in vivo MRI data set can also provide significant characteristics on the spatial sensitivity of cerebral cortex folding geometry based on Monte Carlo simulation. Thus, we proposed a MRI based approach for 3-D brain modeling of near-infrared spectroscopy (NIRS). In the results, the spatial sensitivity profile of the cerebral cortex folding geometry and the arrangement of source-detector separation have being necessarily considered for applications of functional NIRS. The optimal choice of source-detector separation is suggested within 33.5 cm by the received intensity with different source-detector separations and the ratio of received light from the gray and white matter layer is greater than 50%. Additionally, this study has demonstrated the capability of NIRS in not only assessing the functional but also detecting the structural change of the brain by taking advantage of the low scattering and absorption coefficients observed in CSF of sagittal view. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)en_US
dc.language.isoen_USen_US
dc.subjectnear-infrared spectroscopyen_US
dc.subjectMonte Carlo simulationen_US
dc.subjectspatial sensitivityen_US
dc.subjectphoton migrationen_US
dc.subjectbrain structureen_US
dc.subjectdiffuse opticsen_US
dc.subjectMRIen_US
dc.titleBrain structure and spatial sensitivity profile assessing by near-infrared spectroscopy modeling based on 3D MRI dataen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jbio.201200025en_US
dc.identifier.journalJOURNAL OF BIOPHOTONICSen_US
dc.citation.volume6en_US
dc.citation.issue3en_US
dc.citation.spage267en_US
dc.citation.epage274en_US
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000315641100008-
dc.citation.woscount2-
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