標題: | In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging |
作者: | Li, W. -M. Chen, S. -Y. Liu, D. -M. 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | Calcium phosphate;pH-sensitivity;Drug release;Amphiphilic gelatin;MR imaging |
公開日期: | 1-Feb-2013 |
摘要: | An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.actbio.2012.09.023 http://hdl.handle.net/11536/21233 |
ISSN: | 1742-7061 |
DOI: | 10.1016/j.actbio.2012.09.023 |
期刊: | ACTA BIOMATERIALIA |
Volume: | 9 |
Issue: | 2 |
起始頁: | 5360 |
結束頁: | 5368 |
Appears in Collections: | Articles |
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