標題: | Growth of gold nanowires on flexible substrate for highly sensitive biosensing: detection of thrombin as an example |
作者: | Chen, Yu-Liang Lee, Chi-Young Chiu, Hsin-Tien 應用化學系 Department of Applied Chemistry |
公開日期: | 2013 |
摘要: | We demonstrated a facile fabrication of high density Au nanostructures including nanothorns (NTs), nanocorals (NCs), nanoslices (NSs), and nanowires (NWs) which were electrochemically grown on flexible plastic substrates of polyethylene terephthalate (PET). A thrombin-binding aptamer was immobilized on the surfaces of the Au nanostructures to form highly sensitive electrochemical impedance spectroscopic (EIS) biosensors for thrombin recognition. The binding of thrombin to the aptamer sequence was monitored by EIS in the presence of [Fe(CN)(6)]((aq))(3-/4-). The protein (1-50 pM) was detected linearly by the Au nanostructures. Among them, the Au NWs exhibited excellent thrombin detection performances. The biosensor provided high sensitivity, selectivity, and stability due to its high surface area. |
URI: | http://hdl.handle.net/11536/21285 http://dx.doi.org/10.1039/c2tb00010e |
ISSN: | 2050-750X |
DOI: | 10.1039/c2tb00010e |
期刊: | JOURNAL OF MATERIALS CHEMISTRY B |
Volume: | 1 |
Issue: | 2 |
起始頁: | 186 |
結束頁: | 193 |
顯示於類別: | 期刊論文 |