完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Chan, Wen-Ling | en_US |
dc.contributor.author | Yang, Wen-Kuang | en_US |
dc.contributor.author | Huang, Hsien-Da | en_US |
dc.contributor.author | Chang, Jan-Gowth | en_US |
dc.date.accessioned | 2014-12-08T15:29:54Z | - |
dc.date.available | 2014-12-08T15:29:54Z | - |
dc.date.issued | 2013-02-08 | en_US |
dc.identifier.issn | 1758-0463 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1093/database/bat001 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/21440 | - |
dc.description.abstract | RNA interference (RNAi) is a gene silencing process within living cells, which is controlled by the RNA-induced silencing complex with a sequence-specific manner. In flies and mice, the pseudogene transcripts can be processed into short interfering RNAs (siRNAs) that regulate protein-coding genes through the RNAi pathway. Following these findings, we construct an innovative and comprehensive database to elucidate siRNA-mediated mechanism in human transcribed pseudogenes (TPGs). To investigate TPG producing siRNAs that regulate protein-coding genes, we mapped the TPGs to small RNAs (sRNAs) that were supported by publicly deep sequencing data from various sRNA libraries and constructed the TPG-derived siRNA-target interactions. In addition, we also presented that TPGs can act as a target for miRNAs that actually regulate the parental gene. To enable the systematic compilation and updating of these results and additional information, we have developed a database, pseudoMap, capturing various types of information, including sequence data, TPG and cognate annotation, deep sequencing data, RNA-folding structure, gene expression profiles, miRNA annotation and target prediction. As our knowledge, pseudoMap is the first database to demonstrate two mechanisms of human TPGs: encoding siRNAs and decoying miRNAs that target the parental gene. pseudoMap is freely accessible at http://pseudomap.mbc.nctu.edu.tw/. Database URL: http://pseudomap.mbc.nctu.edu.tw/ | en_US |
dc.language.iso | en_US | en_US |
dc.title | pseudoMap: an innovative and comprehensive resource for identification of siRNA-mediated mechanisms in human transcribed pseudogenes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/database/bat001 | en_US |
dc.identifier.journal | DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | en_US |
dc.citation.volume | en_US | |
dc.citation.issue | en_US | |
dc.citation.epage | en_US | |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 生物資訊及系統生物研究所 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institude of Bioinformatics and Systems Biology | en_US |
dc.identifier.wosnumber | WOS:000316179100001 | - |
dc.citation.woscount | 1 | - |
顯示於類別: | 期刊論文 |