標題: | Regioselective and stereoselective benzylidene installation and one-pot protection of D-mannose |
作者: | Patil, Pratap S. Lee, Chia-Chen Huang, Yu-Wen Zulueta, Medel Manuel L. Hung, Shang-Cheng 應用化學系 Department of Applied Chemistry |
公開日期: | 2013 |
摘要: | Oligosaccharide syntheses are an important source of well-defined sugar constructs particularly needed for the evaluation of structure-activity relationships. The chemical assembly of oligosaccharides requires several building blocks, that is, glycosyl donors and acceptors, which are prepared in multistep processes and in a generally tedious and time-consuming manner. Having developed one-pot procedures meant to minimise the effort in sugar building block preparation, we tackled herein the one-pot preparation of fully protected and 2-, 3-, 4-, and 6-alcohol derivatives of D-mannose, a widely distributed monosaccharide. As a consequence of the hydroxyl group pattern of D-mannose, regioselective and stereoselective benzylide-nations were developed and later seamlessly utilised as the first transformation in the one-pot procedure. |
URI: | http://hdl.handle.net/11536/21786 http://dx.doi.org/10.1039/c3ob40079d |
ISSN: | 1477-0520 |
DOI: | 10.1039/c3ob40079d |
期刊: | ORGANIC & BIOMOLECULAR CHEMISTRY |
Volume: | 11 |
Issue: | 16 |
起始頁: | 2605 |
結束頁: | 2612 |
Appears in Collections: | Articles |
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