標題: Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behaviour
作者: Wang, Yen-Jen
Lo, Teng-Yuan
Wu, Chieh-Hsi
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: colloidal chitosan;electrophoretic deposition;nanotopographic surface;cell-specific growth;biomimetic materials
公開日期: 6-Sep-2013
摘要: In this communication, we report a facile nanotopographical control over a stainless steel surface via an electrophoretic deposition of colloidal amphiphilic chitosan for preferential growth, proliferation or migration of vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs). Atomic force microscopy revealed that the colloidal surface exhibited a deposition time-dependent nanotopographical evolution, wherein two different nanotopographic textures indexed by 'kurtosis' (R-kur) value were easily designed, which were termed as 'sharp' (i.e. high peak-to-valley texture) surface and 'flat' (i.e. low peak-to-valley texture) surface. Cellular behaviour of VSMCs and HUVECs on both surfaces demonstrated topographically dependent morphogenesis, adherent responses and biochemical properties in comparison with bare stainless steel. The formation of a biofunctionalized surface upon a facile colloidal chitosan deposition envisions the potential application towards numerous biomedical devices, and this is especially promising for cardiovascular stents wherein a new surface with optimized texture can be designed and is expected to create an advantageous environment to stimulate HUVEC growth for improved healing performance.
URI: http://dx.doi.org/10.1098/rsif.2013.0411
http://hdl.handle.net/11536/22096
ISSN: 1742-5689
DOI: 10.1098/rsif.2013.0411
期刊: JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume: 10
Issue: 86
結束頁: 
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