Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

Title:	Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
Authors:	Lin, Chien-Hung Chang, Tsung-Che Das, Anindya Fang, Ming-Yu Hung, Hui-Chen Hsu, Kai-Cheng Yang, Jinn-Moon von Itzstein, Mark Mong, Kwok Kong T. Hsu, Tsu-An Lin, Chun-Cheng 生物科技學系應用化學系 Department of Biological Science and Technology Department of Applied Chemistry
Issue Date:	2013
Abstract:	A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.
URI:	http://hdl.handle.net/11536/22456 http://dx.doi.org/10.1039/c3ob40624e
ISSN:	1477-0520
DOI:	10.1039/c3ob40624e
Journal:	ORGANIC & BIOMOLECULAR CHEMISTRY
Volume:	11
Issue:	24
Begin Page:	3943
End Page:	3948
Appears in Collections:	Articles

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