標題: Nanowire Field Effect Transistor With its Sub-picomolar Label-free Biosensing Capability Toward a Gene Mutation
作者: Wu, Chi-Chang
Ko, Fu-Hsiang
Su, Ting-Siang
Li, Bo-Syuan
Wu, Wen-Fa
材料科學與工程學系奈米科技碩博班
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
公開日期: 2010
摘要: We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.
URI: http://hdl.handle.net/11536/22669
ISBN: 978-1-4244-3543-2
期刊: INEC: 2010 3RD INTERNATIONAL NANOELECTRONICS CONFERENCE, VOLS 1 AND 2
起始頁: 872
結束頁: 873
Appears in Collections:Conferences Paper