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dc.contributor.authorHu, Jin-Jiaen_US
dc.contributor.authorLiu, Yen-Chingen_US
dc.contributor.authorChen, Guan-Wenen_US
dc.contributor.authorWang, Mei-Xuanen_US
dc.contributor.authorLee, Pei-Yuanen_US
dc.date.accessioned2014-12-08T15:32:23Z-
dc.date.available2014-12-08T15:32:23Z-
dc.date.issued2013-10-01en_US
dc.identifier.issn1617-7959en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s10237-012-0448-xen_US
dc.identifier.urihttp://hdl.handle.net/11536/22735-
dc.description.abstractPrior studies indicated that mechanical loading influences cell turnover and matrix remodeling in tissues, suggesting that mechanical stimuli can play an active role in engineering artificial tissues. While most tissue culture studies focus on influence of uniaxial loading or constraints, effects of multi-axial loading or constraints on tissue development are far from clear. In this study, we examined the biaxial mechanical properties of fibroblast-seeded collagen gels cultured under four different mechanical constraints for 6 days: free-floating, equibiaxial stretching (with three different stretch ratios), strip-biaxial stretching, and uniaxial stretching. Passive mechanical behavior of the cell-seeded gels was also examined after decellularization. A continuum-based two-dimensional Fung model was used to quantify the mechanical behavior of the gel. Based on the model, the value of stored strain energy and the ratio of stiffness in the stretching directions were calculated at prescribed strains for each gel, and statistical comparisons were made among the gels cultured under the various mechanical constraints. Results showed that gels cultured under the free-floating and equibiaxial stretching conditions exhibited a nearly isotropic mechanical behavior, while gels cultured under the strip-biaxial and uniaxial stretching conditions developed a significant degree of mechanical anisotropy. In particular, gels cultured under the equibiaxial stretching condition with a greater stretch ratio appeared to be stiffer than those with a smaller stretch ratio. Also, a decellularized gel was stiffer than its non-decellularized counterpart. Finally, the retained mechanical anisotropy in gels cultured under the strip-biaxial stretching and uniaxial stretching conditions after cell removal reflected an irreversible matrix remodeling.en_US
dc.language.isoen_USen_US
dc.subjectFibroblast-seeded collagen gelsen_US
dc.subjectTissue developmenten_US
dc.subjectMechanical constraintsen_US
dc.subjectMechanical anisotropyen_US
dc.subjectBiaxial mechanical testingen_US
dc.subjectConstitutive modelingen_US
dc.titleDevelopment of fibroblast-seeded collagen gels under planar biaxial mechanical constraints: a biomechanical studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s10237-012-0448-xen_US
dc.identifier.journalBIOMECHANICS AND MODELING IN MECHANOBIOLOGYen_US
dc.citation.volume12en_US
dc.citation.issue5en_US
dc.citation.spage849en_US
dc.citation.epage868en_US
dc.contributor.department機械工程學系zh_TW
dc.contributor.departmentDepartment of Mechanical Engineeringen_US
dc.identifier.wosnumberWOS:000324378900001-
dc.citation.woscount2-
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